Nitric oxide in general does have some minor issues which are:- Diarrhea. Vomiting. Heart palpitations. Breathing problems. Excessive sweating. Dry mouth. Drop in blood pressure levels. Weakness. Nausea. These are the common complaints for most other nitric oxide supplements. Xtreme No supplement does not have these shortcomings. The pill has got natural ingredients whose correct dosage gives you only positive results. Xtreme No makers do not recommend taking it beyond its dosage. If you follow the directions on how to use Xtreme No correctly, you certainly won’t experience any of these possible side-effects.